Gerardo Heiss, a Kenan professor of epidemiology in the UNC School of Public Wellness. In July 2002 after participants had been on the therapy for an average of 5 The trial was stopped.6 years because researchers noticed an increased threat of breast cancer and cardiovascular disease in women randomly assigned to hormone therapy, weighed against those who received a placebo. Since that time, Heiss and additional WHI researchers at collaborating organizations have examined the dangers and benefits experienced by 15, 730 trial individuals who had follow-up appointments from July 2002 to March 2005, after they stopped hormone therapy.56 % each year [n = 281]) compared to the placebo group . This reflects a larger risk of invasive breast cancer and other cancers in the progestin plus estrogen group.In endocytosis, a compartment is established in the cell membrane for the molecule to enter. This compartment – or endosome – needs to be acidic in order for the process to work effectively. The extensive research results show that CLC-5 delivers protons into endosomes, which causes acidification to occur, therefore when it CLC-5 is normally faulty, endocytosis cannot effectively happen. ‘If endocytosis can’t happen we lose vital vitamins and hormones,’ says Dr Lippiat. ‘CLC-5 is actually part of a family group of proteins, some of which are implicated in various other diseases, so these findings could have important effects when we’re searching at the role of other proteins in the same family members.’.. Biocartis also develops an array of clinically relevant exams for different diagnostic areas mainly in neuro-scientific oncology.